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The therapeutic dosages for ADHD or narcolepsy that clinicians prescribe usually are not damaging plenty of to activate the reward technique throughout the CNS, which facilities across the nucleus accumbens. On the other hand, excessively greater dosages produce an overexpression of ΔFosB (a transcriptional activator) in distinct neurons in the st
4 isomers of methylphenidate are attainable, Because the molecule has two chiral centers. One pair of threo isomers and one pair of erythro are distinguished, from which mainly d-threo-methylphenidate displays the pharmacologically preferred results.[122][149] The erythro diastereomers are pressor amines, a property not shared Along with the threo
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